Application of Cell Factories in the Preparation of Mumps Vaccine

Cell factories are advanced cell culture containers with a multilayer structure, and their unique design and efficient space utilization capabilities have brought revolutionary changes to the vaccine industry. This tool is used in the preparation of mumps vaccines.

Cell factories are advanced cell culture containers with a multilayer structure, and their unique design and efficient space utilization capabilities have brought revolutionary changes to the vaccine industry. This tool is used in the preparation of mumps vaccines.

Mumps is an acute respiratory infectious disease caused by the mumps virus, characterized by swelling of the parotid glands. The disease predominantly affects children and adolescents, mostly occurring in the winter and spring seasons. Mumps is widely prevalent in China, with frequent local outbreaks. Clinical manifestations include swelling and pain of the parotid glands, which may affect one or both sides, and it can also involve other glandular organs, leading to orchitis, pancreatitis, and oophoritis. The mumps virus can also cause meningitis and myocarditis, and it is a significant cause of acquired deafness, which is often irreversible. Vaccination with the mumps live attenuated vaccine can achieve good preventive effects.

The mumps vaccine is prepared by inoculating chicken embryo cells with the attenuated mumps virus strain S79. The virus is then cultured in cell factories, harvested, and after adding suitable stabilizers, the virus liquid is lyophilized to produce the vaccine. Cell factories utilize a multilayer structure, ingeniously providing more culture surface in a limited space through vertical stacking. This design allows more cells to be accommodated within the same area of equipment, significantly increasing cell culture density. In the preparation of the mumps vaccine, this means that more cells can be cultured simultaneously, speeding up vaccine production.

In summary, the innovative application of cell factories in the preparation of the mumps vaccine has brought significant changes to the vaccine industry. Their multilayer structure, space-saving design, and high production efficiency provide an advanced and feasible solution for large-scale production, offering reliable support for the prevention and control of infectious diseases.